Bionic implant could help paralyzed people ‘walk with the power of thought’
The team plans to test the stentrode in humans in 2017; they will insert it via a vein and implant it next to the motor cortex, where it will pick up brain signals so the patient can control an exoskeleton just by thinking about it.
Image credit: University of Melbourne
The team is hoping to test the matchstick-sized stent electrode, or “stentrode,” in a group of paralyzed patients with spinal cord injuries in 2017.
The device is inserted via a blood vessel and is deposited in a blood vessel next to the motor cortex – the part of the brain that generates signals that control movement – bypassing the need for complex brain surgery.
The brain-machine interface is not dissimilar to the idea of a heart pacemaker, in that it interacts electrically with tissue using sensors inserted into a vein, except the vein is inside the brain.
The medical innovation is the work of 39 scientists, researchers and engineers from 16 departments at the University of Melbourne in Australia, who report their work so far in a paper published in the journal Nature Biotechnology.
First author and neurologist Dr. Thomas Oxley, who among other things heads the multi-disciplinary vascular bionics lab at Melbourne, says:
“We have been able to create the world’s only minimally invasive device that is implanted into a blood vessel in the brain via a simple day procedure, avoiding the need for high-risk open brain surgery.”
Their goal is to help completely paralyzed patients regain mobility by recording their brain activity and converting those signals into electrical commands that control exoskeletons and prosthetic limbs.
“In essence this is a bionic spinal cord,” explains Dr. Oxley.
The signals could also be used to control wheelchairs and computers, say the researchers.
Pre-clinical trials suggest stentrode is effective, safe for long-term use
The pre-clinical trials described in the paper show that the type of brain activity the stentrode picks up are the sort that can control the movement of bionic limbs.
The researchers carried out experiments on sheep that show the device can record high-quality signals emitted from the motor cortex, and it can be safely inserted via angiography without incurring the risks associated with open brain surgery.
The results suggest the implanted stentrode is safe for long-term use. The researchers were able to successfully record brain activity over many months, and the quality of the recording improved as the device was incorporated into tissue.
Stroke and spinal cord injuries are leading causes of disability, affecting around 1 in 50 people. In the US, nearly 6 million people are living with paralysis.
In Australia – where the stentrode is being developed – around 150,000 people are living with severe disability following a stroke, and around 20,000 people have spinal cord injuries – the typical patient being a 19-year-old male.
The team plans to start the first in-human trial in 2017; the intention is to achieve direct brain control of an exoskeleton in three paralyzed patients.
At the moment, to switch to a different mode like stand, start, stop or turn, the user has to operate a joystick. When the trial patients begin to use the stentrode, it will be the first human-operated device that enables direct control of the switching between these modes.
In the following video, the researchers describe where the idea of the stentrode came from, how they developed it and the technique for implanting it:
The researchers see potential for the stentrode to help patients with Parkinson’s disease, epilepsy and other brain diseases.
The news follows that of another medical innovation Medical News Today learned about recently, where researchers have developed and successfully tested an external electrical forehead patch as a treatment for chronic post-traumatic stress disorder (PTSD). The patch, which is worn during sleep, is powered by a 9-volt battery and sends a weak current to stimulate nerves in the forehead.