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New drug ‘halts disease progression’ in patients with hard-to-treat Hodgkin lymphoma

by on October 23, 2016
 

 

New drug ‘halts disease progression’ in patients with hard-to-treat Hodgkin lymphoma

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A brand new drug has witnessed success in halting disease progression in grown-ups with hard-to-treat Hodgkin lymphoma following stem cell transplantation, based on the outcomes of a phase 3 trial.

white blood cells
Hodgkin lymphoma, is a cancer of the white blood cells, called lymphocytes. This year, more than 9,000 Americans will be diagnosed with the disease.

Lead study author Dr. Craig Moskowitz, a professor of drugs at Memorial Sloan Kettering Cancer Center in New You are able to, NY, and the team publish their findings within the Lancet.

Hodgkin lymphoma, also called Hodgkin disease, is really a cancer from the white-colored bloodstream cells, known as lymphocytes. It’s the most everyday sort of bloodstream cancer found among individuals aged 15-35, and around 9,050 Americans are anticipated to become identified as having the condition this season.

The 2 primary treating Hodgkin lymphoma are chemotherapy and radiotherapy. While nearly all patients react to such treatment, others don’t, or even the cancer returns inside a couple of several weeks.

Of these hard-to-treat patients, high-dose chemotherapy coupled with autologous stem cell transplantation (ASCT) becomes a choice. ASCT involves replacing the stem cells lost from high-dose chemotherapy using the patients’ own healthy stem cells.

However, despite undergoing high-dose chemotherapy and ASCT, around 1 / 2 of patients with hard-to-treat Hodgkin lymphoma don’t react to the therapy or relapse.

For his or her phase 3 trial, Dr. Moskowitz and colleagues attempted to decide if a medication known as brentuximab vedotin (BV) – if provided to patients soon after ASCT – could prevent Hodgkin lymphoma progression.

BV is definitely an antibody that stays with a protein known as CD30, that is located on the the surface of Hodgkin lymphoma cells. By sticking with this protein, BV is able to generate a strong chemotherapy drug straight to the cells of cancer, killing them.

65% of patients given BV didn’t have disease progression 24 months after ASCT

They enrolled 329 patients aged 18 or older with Hodgkin lymphoma who have been at high-risk of disease progression or relapse following ASCT.

After undergoing ASCT, patients were at random allotted to receive either 16 cycles of BV intravenous infusions once every 3 days or perhaps a placebo.

They discovered that at 24 months after treatment, 65% of patients who received BV didn’t have cancer progression, in contrast to 45% of patients who received the placebo. Typically, BV-treated patients survived for 43 several weeks without disease progression, in contrast to only 24 several weeks for individuals who received the placebo.

As it is unlikely patients will relapse 24 months after ASCT, Dr. Moskowitz states just about all patients who experienced no disease progression during follow-up could be cured.

Some patients given BV did experience negative effects, the most typical which were numbness because of peripheral nerve damage and occasional white-colored bloodstream cell count. They states, however, the drug was generally well tolerated.

Commenting around the results, Dr. Moskowitz states:

“The end result is that BV is an extremely effective drug in poor-risk Hodgkin lymphoma also it spares patients in the dangerous results of further traditional chemotherapy by breaking lower within the cell leading to less toxicity.

No medication currently available has already established such dramatic leads to patients with hard-to-treat Hodgkin lymphoma.”

Within an editorial from the study, Prof. Andreas Engert, from the College Hospital of Perfume in Germany, states the trial establishes a “promising new treatment approach” for patients with Hodgkin lymphoma who’re at high-risk of disease progression.

He notes, however, that the almost 50% survival at 24 several weeks for patients within the placebo group enhances the question whether most of the patients incorporated were really at high-risk of relapse.

“An worldwide consortium is presently reassessing the result of risks in patients with relapsed Hodgkin lymphoma to define a higher-risk patient population looking for consolidation treatment,” he adds. “We expect to some better meaning of patients with relapsed Hodgkin lymphoma who should receive consolidation treatment with brentuximab vedotin.”

In December 2014, Medical News Today reported on another study by Dr. Moskowitz and colleagues, where the team found two PD-1 inhibitors – that block the PD-1 protein located on the the surface of Hodgkin lymphoma cells – could boost defense mechanisms activity of patients using the disease, helping them fight cancer.

 

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